Table 1

SARs of N-linked aryl benzothiazoles. Mean EC₅₀ values ± S.D. and number of replicates (n) for aryl amides with the N-linked aryl benzothiazole scaffold.

	R₂	R₃	X	R₄	EC₅₀ (μM)	n
9	H	H	CH	Me	0.063 ± 0.028	2
10	Me	H	CH	H	0.13 ± 0.07	2
11	H	Me	CH	H	0.17 ± 0.10	2
12	H	Cl	CH	H	7.96 ± 1.71	2
13	H	H	N	H	0.98 ± 0.12	2
14	H	H	CH	Me	0.080 ± 0.018	3
15	H	H	CH	H	0.27 ± 0.03	2
16	H	H	CH	Me	0.092 ± 0.005	2
17	H	H	CH	H	0.47 ± 0.05	2
18	Me	H	CH	H	0.48	1
19	H	H	CH	Me	0.45 ± 0.25	2
20	H	H	CH	Me	7.66 ± 2.53	2
21	H	H	CH	Me	0.084 ± 0.014	2
22	H	H	CH	Me	1.68 ± 0.09	2
23	H	H	N	H	0.15 ± 0.01	2
24	H	H	N	H	0.38 ± 0.04	2