Table 2

SARs of N-linked aryl benzoxazoles. Mean EC₅₀ values ± S.D. and number of replicates (n) for aryl amides with the N-linked aryl benzoxazole scaffold.

	R₂	R₃	EC₅₀ (μM)	n
28	H	H	1.18 ± 0.01	2
29	H	H	0.31 ± 0.00	2
30	H	Me	0.073 ± 0.019	2
31	OMe	H	0.32 ± 0.11	2
32	Cl	H	0.64 ± 0.24	2
33	H	H	>10	2
34	H	H	> 10	1
35	H	H	0.36	1
36	H	H	0.74 ± 0.04	2
37	H	H	0.17 ± 0.01	2