Plasma, brain, and spinal cord levels of MIV-247 and pregabalin
| Group | Compound assessed | Dose | Time | Cplasma | Cbrain | Cspinal cord |
|---|---|---|---|---|---|---|
| µmol/kg | h | µmol/l | µmol/kg | |||
| MIV-247 | MIV-247 | 50 | 3.5 | 0.88 ± 0.5 | 0.20 ± 0.2 | 0.14 ± 0.06 |
| MIV-247 and pregabalin | MIV-247 | 50 and 38 | 3.5 | 0.51 ± 0.2 | 0.10 ± 0.02 | 0.07 ± 0.04 |
| Pregabalin | Pregabalin | 38 | 3.5 | 5.3 ± 2.1 | 3.1 ± 0.9 | 2.3 ± 0.7 |
| MIV-247 and pregabalin | Pregabalin | 50 and 38 | 3.5 | 7.0 ± 1.8 | 3.2 ± 0.5 | 1.9 ± 0.4 |
Data are mean ± S.D., n = 3 per group. Animals are from satellite noninjured animals used for PK.