Treatment Group | Vortioxetine | Scopolamine | ||||
---|---|---|---|---|---|---|
Plasma (µM) | Brain (µmol/kg) | Brain:Plasma | Plasma (nM) | Brain (nmol/kg) | Brain:Plasma | |
Scopolamine (0.1 mg/kg, s.c., 30 minutes) | 0 | 0 | 0 | 60 ± 6.2 | 330 ± 60 | 5.7 ± 1.1 |
Vortioxetine (10 mg/kg, s.c., 1 hour) | 2.3 ± 0.1a | 34 ± 2.6 | 15 ± 1.1 | 0 | 0 | 0 |
Vortioxetine (10 mg/kg, s.c., 1 hour) + scopolamine (0.1 mg/kg, s.c., 30 minutes) | 1.9 ± 0.08 | 34 ± 2.9 | 17 ± 1.4 | 74 ± 7.1 | 340 ± 60 | 4.6 ± 0.6 |
↵a Significant difference from vortioxetine + scopolamine group.