TABLE 2

Fatty acid amide hydrolase (FAAH) inhibitors (PF-3845 and URB597), ABHD6 inhibitors (KT182 and KT195), and the cyclooxygenase-2 (COX2) selective inhibitor valdecoxib do not substitute for the discriminative stimulus effects of SA-57 (10 mg/kg) in C57BL/6J mice and do not affect response ratesa

EnzymeDrug (mg/kg)% SA-57 SubstitutionNose Pokes/Min
mg/kg±S.E.M.±S.E.M.
FAAHVehicle0.6 ± 0.547.5 ± 4.9
PF-3845 (10)1.5 ± 0.534.4 ± 3.8
PF-3845 (30)0.7 ± 0.238.9 ± 3.5
URB597 (10)2.1 ± 1.036.9 ± 5.6
ABHD6Vehicle1.1 ± 0.646.5 ± 2.6
KT182 (1)1.4 ± 0.741.1 ± 3.5
KT182 (2)1.4 ± 0.843.5 ± 2.4
KT195 (40)0.8 ± 0.338.1 ± 3.1
COX2Vehicle1.1 ± 0.646.5 ± 2.6
Valdecoxib (10)1.1 ± 0.731.9 ± 3.9
  • a Values represent mean ± S.E.M.; n = 7 or 8 mice/group.