TABLE 1

Cannaboid 1 receptor (CB1) receptors mediate the discriminative stimulus effects of the SA-57 (10 mg/kg) training dose

The CB1 receptor antagonist rimonabant (3 mg/kg) significantly blocked the discriminative stimulus effects of SA-57 (10 mg/kg) as well as substitution of CP55,940 (0.1 mg/kg). The CB2 receptor antagonist SR144528 (3 mg/kg), the TRPV1 receptor antagonist capsazepine (5 mg/kg), and the PPARα receptor antagonist GW6471 (2 mg/kg) did not block the SA-57 (10 mg/kg) discriminative stimulus. The vehicle-vehicle and rimonabant-vehicle conditions are the same as those used in Fig. 9. Values represent mean ± S.E.M. n = 6–8 mice/group.

DrugAntagonist% SA-57 Substitution ± S.E.M.Nose Pokes/min ± S.E.M.
VehicleVehicle12.8 ± 9.438.9 ± 3
Rimonabant4.0 ± 1.224.9 ± 3
SR1445280.7 ± 0.336.6 ± 3.8
Capsazepine1.3 ± 0.420.1 ± 2.6
GW64710.3 ± 2.624.6 ± 3.1
SA-57Vehicle95.7 ± 1.727.3 ± 1.9
Rimonabant3.4 ± 1.220.1 ± 2.5
SR14452898 ± 1.530.5 ± 5.4
Capsazepine86 ± 12.215.7 ± 2.9
GW647196.5 ± 1.319.0 ± 2
CP55,940Vehicle82.5 ± 1133.1 ± 3.3
Rimonabant10.4 ± 5.720.7 ± 4.9