Body and organ weights and cardiac and renal indices
Values are expressed as the mean ± S.E.M.
| Group | Ctrl (n = 10) | Ctrl+GW (n = 9) | AngII (n = 10) | AngII+GW (n = 10) | AngII+GW+GSK (n = 9) |
|---|---|---|---|---|---|
| BW initial (g) | 26.31 ± 0.26 | 25.87 ± 0.32 | 26.23 ± 0.29 | 25.96 ± 0.33 | 25.96 ± 0.40 |
| BW final (g) | 27.14 ± 0.63 | 26.33 ± 0.23 | 27.07 ± 0.41 | 25.48 ± 0.23*,# | 26.21 ± 0.34† |
| Δ Weight (g) | 0.83 ± 0.26 | 0.46 ± 0.32 | 0.84 ± 0.29 | −0.48 ± 0.23*,# | 0.25 ± 0.27 |
| Food intake (g/day) | 2.81 ± 0.06 | 2.68 ± 0.12 | 2.79 ± 0.07 | 2.70 ± 0.09 | 2.75 ± 0.06 |
| Water intake (ml/day) | 3.41 ± 0.14 | 3.42 ± 0.12 | 3.44 ± 0.10 | 3.43 ± 0.11 | 3.45 ± 0.09 |
| HW (mg) | 122.91 ± 5.3 | 122.03 ± 4.2 | 148.26 ± 5.4 | 130.94 ± 5.3 | 157.82 ± 7.3 |
| LVW (mg) | 89.01 ± 2.7 | 91.41 ± 1.1 | 108.89 ± 2.7 | 99.60 ± 3.5 | 114.68 ± 9.3 |
| KW (mg) | 149.96 ± 4.8 | 157.30 ± 2.7 | 151.20 ± 2.9 | 159.26 ± 6.7 | 151.93 ± 2.9 |
| HW/tibia length | 6.14 ± 0.41 | 6.12 ± 0.33 | 7.51 ± 0.37* | 6.49 ± 0.31# | 7.76 ± 0.54† |
| LVW/tibia length | 4.71 ± 0.18 | 4.56 ± 0.12 | 5.30 ± 0.21** | 4.74 ± 0.12# | 5.68 ± 0.36† |
| KW/tibia length | 7.56 ± 0.10 | 7.71 ± 0.10 | 7.51 ± 0.19 | 7.35 ± 0.28 | 7.72 ± 0.30 |
BW, body weight; Ctrl, control; GSK, GSK0660; GW, GW0742; HW, heart weight; KW, kidney weight; LVW, left ventricle weight
↵* P < 0.05 versus control group; **P < 0.01 versus control group; #P < 0.05 versus AngII group; †P < 0.05 versus AngII+GW group.