Analyte | 48-h Recovery | Percentage of BUP Dose | CLrb |
---|---|---|---|
nmol | l/h | ||
Enantiomer | |||
R-BUP | 1106 (873–1401) | 0.27 (0.21–0.34) | 1.00 (0.71–1.41) |
S-BUP | 197 (164–238) | 0.05 (0.04–0.06) | 1.07 (0.79–1.45) |
RR-OHBUP | 4180 (3167–5517) | 1.00 (0.76–1.32) | 0.14 (0.10–0.18) |
SS-OHBUP | 655 (508–845) | 0.16 (0.12–0.20) | 1.28 (1.03–1.59) |
RR-THRHBUP | 10,361 (8433–12,729) | 2.48 (2.02–3.05) | 3.88 (3.02–4.97) |
SS-THRHBUP | 4391 (2887–6679) | 1.05 (0.69–1.60) | 3.18 (2.01–5.03) |
SR-ERYHBUP | 2120 (1710–2628) | 0.51 (0.41–0.63) | 2.51 (1.95–3.24) |
RS-ERYHBUP | 374 (282–497) | 0.09 (0.07–0.12) | 2.36 (1.64–3.40) |
Glucuronide | |||
RR-OHBUP Gluca | 15,751 (12,598–19,693) | 3.78 (3.02–4.72) | — |
SS-OHBUP Gluca | 5301 (4228–6646) | 1.27 (1.01–1.59) | — |
RR-THRHBUP Gluc | 3782 (2879–4969) | 0.91 (0.69–1.19) | — |
SS-THRHBUP Gluc | 969 (827–1135) | 0.23 (0.20–0.27) | — |
SR-ERYHBUP Gluc | 1878 (1569–2247) | 0.45 (0.38–0.54) | — |
RS-ERYHBUP Gluc | 382 (302–482) | 0.09 (0.07–0.12) | — |
↵a RR-OHBUP and SS-OHBUP glucuronides represent nanomolar equivalents relative to THRHBUP glucuronides with the same isomeric configuration.
↵b CLr is calculated as the ratio of the cumulative amount excreted in the urine by 48 hours to the area under the plasma concentration-time curve during the same interval.