Treatment | Drug | Dose | Interaction | Post Hoc Test |
---|---|---|---|---|
Cocaine versus saline substitution (n = 30, Fig. 3, A–C) | F1,116 = 48.6, P < 0.001 | F4,116 = 39.2, P < 0.001 | F4,166 = 42.3, P < 0.001 | 0.10 mg/kg per injection, t = 8.55, P < 0.001 |
0.32 mg/kg per injection, t = 12.3, P < 0.001 | ||||
DTG versus saline substitution (n = 12, Fig. 3B) | F1,44 = 15.7, P = 0.002 | F4,44 = 13.5, P < 0.001 | F4,44 = 13.1, P < 0.001 | 0.32 mg/kg per injection, t = 3.33, P = 0.002 |
1.0 mg/kg per injection, t = 7.68, P < 0.001 | ||||
PRE-084 versus saline substitution (n = 18, Fig. 3B) | F1,68 = 23.6, P < 0.001 | F4,68 = 20.0, P < 0.001 | F4,68 = 20.9, P < 0.001 | 0.10 mg/kg per injection, t = 5.49, P < 0.001 |
0.32 mg/kg per injection, t = 8.91, P < 0.001 | ||||
(+)-Pentazocine versus saline substitution (n = 18, Fig. 3B) | F1,68 = 21.5, P < 0.001 | F4,68 = 15.7, P < 0.001 | F4,68 = 16.4, P < 0.001 | 0.10 mg/kg per injection, t = 5.14, P < 0.001 |
0.32 mg/kg per injection, t = 8.03, P < 0.001 | ||||
AZ 66 versus saline substitution (n = 6, Fig. 3C) | F1,20 = 5.28, P = 0.007 | F4,20 = 5.81, P = 0.003 | F4,20 = 5.60, P = 0.003 | 0.10 mg/kg per injection, t = 4.07, P < 0.001 (Δ = 0.014) |
0.32 mg/kg per injection, t = 2.86, P = 0.008 (Δ = 0.010) | ||||
CM 304 versus saline substitution (n = 6, Fig. 3C) | F1,20 = 13.2, P = 0.015 | F4,20 = 0.451, P = 0.770 | F4,20 = 7.57, P < 0.001 | EXT, t = 5.28, P < 0.001 (Δ = −0.029) |
0.32 mg/kg per injection, t = 4.18, P = 0.002 (Δ = −0.023) | ||||
3.2 mg/kg per injection, t = 2.61, P = 0.027 (Δ = −0.014) | ||||
CM 353 versus saline substitution (n = 6, Fig. 3C) | F1,20 = 26.4, P = 0.070 | F4,20 = 22.0, P < 0.001 | F4,20 = 22.1, P = 0.501 | N.S. |
CM 398 versus saline substitution (n = 6, Fig. 3C) | F1,20 = 2.09, P = 0.208 | F4,20 = 4.73, P = 0.008 | F4,20 = 2.52, P = 0.074 | N.S. |
(±)-SM 21 versus saline substitution (n = 6, Fig. 3C) | F1,20 = 8.67, P = 0.032 | F4,20 = 4.32, P = 0.011 | F4,20 = 1.89, P = 0.152 | EXT, t = 3.33, P = 0.014 (Δ = -0.028) |
0.10 mg/kg per injection, t = 3.36, P = 0.013 (Δ = −0.018), | ||||
1.0 mg/kg per injection, t = 2.48, P = 0.044 (Δ = −0.020) | ||||
SN 79 versus saline substitution (n = 6, Fig. 3C) | F1,20 = 6.99, P = 0.046 | F4,20 = 2.35, P = 0.089 | F4,20 = 2.76, P = 0.056 | EXT, t = 3.53, P = 0.011 (Δ = −0.008) |
1.0 mg/kg per injection, t = 2.52, P = 0.042 (Δ = 0.011) | ||||
SN 167 versus saline substitution (n = 6, Fig. 3C) | F1,20 = 6.18, P = 0.055 | F4,20 = 3.15, P = 0.037 | F4,20 = 0.621, P = 0.652 | EXT, t = 2.54, P = 0.044 (Δ = 0.008) |
0.10 mg/kg per injection, t = 2.73, P = 0.034 (Δ = 0.108) |
N.S., nonsignificant.