TABLE 4

Statistical analyses of effects of various compounds on self administration of cocaine as shown in Fig. 5

Δ values were calculated as a subtraction of response rates maintained by cocaine pretreated with test compounds from those with saline vehicle.

Treatment	Self Administered Drug Dose	Pretreatment Dose (i.p.)	Interaction	Post Hoc Test
AZ 66 (i.p.) before cocaine self administration	F_4,60 = 5.22, P = 0.005	F_3,60 = 2.41, P = 0.107	F_12,60 = 2.67, P = 0.006	1.0 mg/kg (i.p.) at 0.32 mg/kg per injection, t = 4.24, P < 0.001
				3.2 mg/kg (i.p.) at 0.32 mg/kg per injection, t = 3.54, P = 0.004
				10 mg/kg (i.p.) at 0.32 mg/kg per injection, t = 5.05, P < 0.001
CM 304 (i.p.) before cocaine self administration	F_4,60 = 7.44, P < 0.001	F_3,60 = 4.52, P = 0.019	F_12,60 = 3.25, P = 0.001	1.0 mg/kg (i.p.) at 0.32 mg/kg per injection, t = 5.53, P = 0.010 (Δ = 0.026)
CM 304 (i.p.) before cocaine self administration	F_4,60 = 7.44, P < 0.001	F_3,60 = 4.52, P = 0.019	F_12,60 = 3.25, P = 0.001	3.2 mg/kg (i.p.) at 0.32 mg/kg per injection, t = 3.28, P < 0.001 (Δ = 0.043)
CM 353 (i.p.) before cocaine self administration	F_4,60 = 5.77, P = 0.003	F_3,60 = 2.37, P = 0.112	F_12,60 = 3.04, P = 0.002	10 mg/kg (i.p.) at 0.32 mg/kg per injection, t = 3.88, P = 0.001
CM 398 (i.p.) before cocaine self administration	F_4,60 = 4.45, P < 0.001	F_3,60 = 12.7, P = 0.020	F_12,60 = 6.22, P < 0.001	1.0 mg/kg (i.p.) at 0.10 mg/kg per injection, t = 2.91, P = 0.030 (Δ = 0.031)
				0.32 mg/kg (i.p.) at 0.32 mg/kg per injection, t = 3.72, P = 0.002 (Δ = −0.024)
				3.2 mg/kg (i.p.) at 0.32 mg/kg per injection, t = 7.65, P < 0.001 (Δ = 0.065)
(±)-SM 21 (i.p.) before cocaine self administration	F_4,60 = 13.1, P < 0.001	F_3,60 = 6.57, P = 0.005	F_12,60 = 8.19, P < 0.001	3.2 mg/kg (i.p.) at 0.10 mg/kg per injection, t = 3.92, P = 0.001 (Δ = −0.053)
				32 mg/kg (i.p.) at 0.10 mg/kg per injection, t = 3.44, P = 0.007 (Δ = −0.046)
				3.2 mg/kg (i.p.) at 0.32 mg/kg per injection, t = 4.09, P < 0.001 (Δ = 0.045)
				32 mg/kg (i.p.) at 0.32 mg/kg per injection, t = 3.30, P = 0.010 (Δ = −0.055)
SN 79 (i.p.) before cocaine self administration	F_4,60 = 13.0, P < 0.001	F_3,60 = 7.91, P = 0.002	F_12,60 = 6.43, P < 0.001	17 mg/kg (i.p.) at 0.10 mg/kg per injection, t = 4.16, P < 0.001 (Δ = 0.092)
				3.2 mg/kg (i.p.) at 0.32 mg/kg per injection, t = 3.89, P = 0.001 (Δ = 0.086)
				17 mg/kg (i.p.) at 0.32 mg/kg per injection, t = 4.15, P < 0.001 (Δ = 0.092)
SN 167 (i.p.) before cocaine self administration	F_4,60 = 7.16, P < 0.001	F_3,60 = 4.87, P = 0.015	F_12,60 = 3.17, P = 0.001	17 mg/kg (i.p.) at 0.32 mg/kg per injection, t = 3.77, P = 0.002 (Δ = 0.023)