AZ 66 (i.p.) before cocaine self administration | F4,60 = 5.22, P = 0.005 | F3,60 = 2.41, P = 0.107 | F12,60 = 2.67, P = 0.006 | 1.0 mg/kg (i.p.) at 0.32 mg/kg per injection, t = 4.24, P < 0.001 |
3.2 mg/kg (i.p.) at 0.32 mg/kg per injection, t = 3.54, P = 0.004 |
10 mg/kg (i.p.) at 0.32 mg/kg per injection, t = 5.05, P < 0.001 |
CM 304 (i.p.) before cocaine self administration | F4,60 = 7.44, P < 0.001 | F3,60 = 4.52, P = 0.019 | F12,60 = 3.25, P = 0.001 | 1.0 mg/kg (i.p.) at 0.32 mg/kg per injection, t = 5.53, P = 0.010 (Δ = 0.026) |
3.2 mg/kg (i.p.) at 0.32 mg/kg per injection, t = 3.28, P < 0.001 (Δ = 0.043) |
CM 353 (i.p.) before cocaine self administration | F4,60 = 5.77, P = 0.003 | F3,60 = 2.37, P = 0.112 | F12,60 = 3.04, P = 0.002 | 10 mg/kg (i.p.) at 0.32 mg/kg per injection, t = 3.88, P = 0.001 |
CM 398 (i.p.) before cocaine self administration | F4,60 = 4.45, P < 0.001 | F3,60 = 12.7, P = 0.020 | F12,60 = 6.22, P < 0.001 | 1.0 mg/kg (i.p.) at 0.10 mg/kg per injection, t = 2.91, P = 0.030 (Δ = 0.031) |
0.32 mg/kg (i.p.) at 0.32 mg/kg per injection, t = 3.72, P = 0.002 (Δ = −0.024) |
3.2 mg/kg (i.p.) at 0.32 mg/kg per injection, t = 7.65, P < 0.001 (Δ = 0.065) |
(±)-SM 21 (i.p.) before cocaine self administration | F4,60 = 13.1, P < 0.001 | F3,60 = 6.57, P = 0.005 | F12,60 = 8.19, P < 0.001 | 3.2 mg/kg (i.p.) at 0.10 mg/kg per injection, t = 3.92, P = 0.001 (Δ = −0.053) |
32 mg/kg (i.p.) at 0.10 mg/kg per injection, t = 3.44, P = 0.007 (Δ = −0.046) |
3.2 mg/kg (i.p.) at 0.32 mg/kg per injection, t = 4.09, P < 0.001 (Δ = 0.045) |
32 mg/kg (i.p.) at 0.32 mg/kg per injection, t = 3.30, P = 0.010 (Δ = −0.055) |
SN 79 (i.p.) before cocaine self administration | F4,60 = 13.0, P < 0.001 | F3,60 = 7.91, P = 0.002 | F12,60 = 6.43, P < 0.001 | 17 mg/kg (i.p.) at 0.10 mg/kg per injection, t = 4.16, P < 0.001 (Δ = 0.092) |
3.2 mg/kg (i.p.) at 0.32 mg/kg per injection, t = 3.89, P = 0.001 (Δ = 0.086) |
17 mg/kg (i.p.) at 0.32 mg/kg per injection, t = 4.15, P < 0.001 (Δ = 0.092) |
SN 167 (i.p.) before cocaine self administration | F4,60 = 7.16, P < 0.001 | F3,60 = 4.87, P = 0.015 | F12,60 = 3.17, P = 0.001 | 17 mg/kg (i.p.) at 0.32 mg/kg per injection, t = 3.77, P = 0.002 (Δ = 0.023) |