TABLE 2

Inhibition by various compounds of specific binding to the DAT, σ₁, or σ₂ receptors

K_i values are presented with 95% confidence limits in parentheses.

Compound	σ₁K_i Value	σ₂K_i Value	σ_1/σ₂	DAT K_i Value
CM 304	0.684 (0.552–0.847)	388 (215–702)	0.002	6840 (5270–8880)
BD 1063^{^a}	8.81 (7.15–10.9)	626 (447–876)	0.014	8020 (7100–9060)
AZ 66	4.70 (4.06–5.45)	1.35 (0.911–2.00)	3.48	1950 (1740–2190)
SN 79	78.6 (65.2–94.7)	11.3 (7.91–16.3)	6.96	1820 (1590–2070)
SN 167	392 (317–485)	16.1 (10.4–24.9)	24.3	949 (821–1100)
CM 398	1490 (1200–1860)	4.50 (2.78–7.27)	331	11,100 (9940–12,400)
CM 353	1120 (905–1380)	4.48 (2.66–7.55)	250	206 (184–229)
(±)-SM 21	2760 (1700–4470)	263 (166–409)	10.5	293 (264–326)

Low-affinity site K_i values for compounds for which σ2 binding modeled better for two sites than one site are as follows: CM 304, 12,800 (87.7–1,860,000); (±)-SM 21, 30,800 (4730–200,000); SN 79, 9130 (2860–29,100); SN 167, 373,000 (89,500–1,560,000); and CM 398, 180,000 (2230–14,500,000).
↵^a The values for these compounds are those reported in the literature by Garcés-Ramírez et al. (2011) using methods identical to those in our study.