Concentrations of (−)-naloxone and (+)-naloxone in the brain 15 minutes after a subcutaneous injection (n = 4–6 in each group)
Values are means ± S.E.M.
| Drug | Dose | Concentration in Brain |
|---|---|---|
| mg/kg | nmol/g | |
| (−)-Naloxone | 0.1 | 0.092 ± 0.007a |
| 1 | 0.832 ± 0.025 | |
| (+)-Naloxone | 0.1 | 0.066 ± 0.002a |
| 1 | 0.736 ± 0.043 | |
| 10 | 6.933 ± 0.554 |
↵a Values from results presented in Fig. 1.