TABLE 2

Effects of C-type natriuretic peptide (CNP) on pressure-volume relations at rest and during exercise after heart failure (HF) Values are means ± S.E. (n = 10).

	Before HF	After HF
	Normal Control	HF Control		CNP-Treated
	Rest	Rest	Exercise	Rest	Exercise
E_ES (mm Hg/ml)	6.8 ± 1.1	4.4 ± 0.3^****	3.9 ± 0.2^*	5.6 ± 0.3^**	6.4 ± 0. 3 ^^, ^**
E_ES/E_A	0.98 ± 0.03	0.38 ± 0.04^****	0.32 ± 0.03	0.64 ± 0.06^**	0.87 ± 0.08 ^^, ^**
M_SW (mm Hg)	89.7 ± 5.3	60.2 ± 3.6^****	52.5 ± 3.3^*	68.5 ± 3.1^**	79.7 ± 2.6 ^^, ^**
SW/PVA	0.61 ± 0.02	0.43 ± 0.04^****	0.38 ± 0.03^*	0.51 ± 0.02^**	0.57 ± 0.02 ^^, ^**

E_ES, slope of linear P_ES-V_ES relation; M_SW, slope of SW-V_ED relation; PVA, LV pressure-volume area; SW, stroke work.
↵* P < 0.05, HF exercise versus HF rest.
↵** P < 0.05, CNP rest versus HF control rest.
↵*** P < 0.05, HF CNP exercise versus HF control exercise.
↵**** P < 0.05 HF control rest versus normal control rest.