TABLE 1

Time course changes in blood glucose level and mechanical allodynic threshold in mice injected with streptozotocin (STZ)

Streptozotocin (200 mg/kg i.p., n = 10) or vehicle (distilled water, n = 10) were administered by intraperitoneal injection at 5 ml/kg. The data are expressed as mean ± S.E.M.

Time	Blood Glucose Levels	Paw Withdrawal Threshold
Time	STZ Treated	Vehicle	STZ Treated
days	mg/ml	g
0	149.4 ± 4.3	4.1 ± 0.22	4.3 ± 0.21
2	386.5 ± 20.1^*	—	—
7	476.2 ± 18.2^*	4.0 ± 0.23	2.1 ± 0.26
14	496.0 ± 11.1^*	4.2 ± 0.31	1.3 ± 0.44^*
21	529.3 ± 12.7^*	4.3 ± 0.22	1.2 ± 0.16^*
28	514.6 ± 17.4^*	4.4 ± 0.21	1.2 ± 0.33^*

↵* P < 0.05 versus time 0 and vehicle at the respective time points.