TABLE 3 Correlation between neurosteroid modulation of tonic current and anticonvulsant profiles in the 6-Hz seizure model in mice
E1 μM values represent the mean normalized tonic current responses of drug at 1 μM concentration coapplied with 1 μM GABA. The GABA 1 μM tonic current was 0.66 ± 0.22 pA/pF, 19.6 pA. E3μMvalues represent the mean normalized tonic current responses of drug at 3 μM concentration coapplied with 1 μM GABA. The GABA 3 μM tonic current was 1.35 ± 0.23 pA/pF, 33.5 pA. EF values represent the effective functional concentration of drug (nanomolar) required to double or triple the 1 μM GABA response. The 6-Hz test ED50 values represent the dose in milligrams per kilogram that protected 50% of animals in the 6-Hz seizure stimulation test. 95% confidence intervals are listed in parentheses, according to a normal distribution.