Neurosteroid-mediated potentiation of tonic currents by 1 uM GABA
Values derived from fold potentiation of mean, normalized tonic current response to 1 uM GABA, (INS/IGABA). INS is the mean, normalized tonic current response to neurosteroid at the given concentration plus 1 uM GABA from Figure 6 Tonic current responses were recorded from voltage-clamped (−65 mV) DGGCs from WT, female (diestrous stage) mice. All mean values are representative of four to eight cells per neurosteroid and concentration.
| Compound | Neurosteroid Potentiation | |||
|---|---|---|---|---|
| 0.1 μM | 0.3 μM | 1.0 μM | 3.0 μM | |
| AP | 2.50 | 2.94 | 4.36 | 10.98 |
| 5β-AP | 0.76 | 1.88 | 2.24 | 6.47 |
| 3β-AP | 0.76 | 0.76 | 0.76 | 0.77 |
| THDOC | 1.01 | 1.94 | 3.52 | 9.24 |
| GX | 1.61 | 2.76 | 3.47 | 8.89 |
| ALFX | 0.88 | 1.32 | 1.98 | 7.30 |
| ORG-20599 | 1.88 | 3.32 | 4.70 | 9.41 |
| AD | 0.94 | 1.09 | 1.30 | 2.95 |
| AN | 0.92 | n.d. | 1.47 | 2.15 |
| ETIO | 0.91 | n.d. | 1.20 | 1.97 |