TABLE 1

Summary of DCF-AG uptake kinetics mediated by OATP2B1

Each value represents the mean ± standard error of the mean from three studies (n = 2 replicates per study). *P < 0.05 for pH 6.0 versus pH 7.4.

Media pHVmaxKmUptake CLintPdif
pmol/min 
per milligramμMμl/min 
per milligramμl/min 
per milligram
6.027.8 ± 4.1*15.2 ± 0.81.82 ± 0.190.0522 ± 0.0120*
7.417.6 ± 1.514.3 ± 0.11.23 ± 0.110.0245 ± 0.0030
  • CLint, intrinsic uptake clearance.