PK of UR-1102 and benzbromarone in tufted capuchin monkeys on the 1st day of dosing
| Group | Cmax | Tmax | t1/2 | AUC0-inf | |
|---|---|---|---|---|---|
| μg/ml | h | h | mg*h/ml | ||
| UR-1102 | 3 mg/kg | 8.96 ± 1.74 | 0.6 ± 0.2 | 4.7 ± 0.9 | 26.2 ± 8.1 |
| 10 mg/kg | 42.4 ± 12.8 | 0.5 ± 0.0 | 4.2 ± 1.1 | 108 ± 51 | |
| 30 mg/kg | 92.9 ± 21.0 | 0.8 ± 0.3 | 3.3 ± 0.8 | 257 ± 60 | |
| Benzbromarone | 3 mg/kg | 4.25 ± 1.49 | 1.7 ± 0.5 | 2.0 ± 0.9 | 14.8 ± 4.6 |
| 10 mg/kg | 10.0 ± 2.7 | 1.7 ± 0.5 | 2.0 ± 1.0 | 37.2 ± 15.3 | |
| 30 mg/kg | 21.0 ± 5.5 | 1.5 ± 0.5 | 2.8 ± 0.3 | 70.4 ± 22.6 | |
| 100 mg/kg | 43.7 ± 9.7 | 1.8 ± 0.4 | 2.8 ± 0.7 | 172 ± 59 |
Data represents mean ± S.D. (n = 6).