TABLE 2

Summary of in vitro COX inhibition assays

IC50 values reflect the mean ± standard error of the mean from three experiments (n = 2 replicates per experiment).

CompoundCOX-1 IC50COX-2 IC50
μMμM
SC-560 (COX-1 selective)0.00166 ± 0.00022N.D.
DuP-697 (COX-2 selective)N.D.0.00714 ± 0.0007
DCF0.0206 ± 0.00370.103 ± 0.005
OH-DCF0.375 ± 0.07521.2 ± 0.3
DCF-AG0.620 ± 0.1052.91 ± 0.36
  • N.D., not determined.