Baseline values of ICI, MVP, plasma noradrenaline and adrenaline, and blood pressure prior to bombesin administration in each group of Wistar rats
Values are presented as means ± S.E.M.
| Evaluation parameters | Vehicle (n = 5) | BB (n = 5) | ADX Plus BB (n = 6) | Non-ADX (n = 10) |
|---|---|---|---|---|
| ICI (s) | 233 ± 66 | 172 ± 11 | 169 ± 25 | 207 ± 38 |
| MVP (cmH2O) | 33.0 ± 3.4 | 35.3 ± 5.1 | 41.3 ± 2.5 | 34.2 ± 2.9 |
| Noradrenaline (pg/ml) | 258 ± 22 | 220 ± 32 | 314 ± 50 | 239 ± 19 |
| Adrenaline (pg/ml) | 107 ± 37 | 178 ± 42 | 31 ± 19* | 142 ± 29† |
| Systolic blood pressure (mmHg) | 154.1 ± 9.6 | 153.9 ± 9.6 | 140.2 ± 6.2 | 154.0 ± 6.3 |
| Mean blood pressure (mmHg) | 101.4 ± 9.7 | 105.0 ± 8.0 | 93.7 ± 6.4 | 103.2 ± 5.8 |
| Diastolic blood pressure (mmHg) | 75.1 ± 9.7 | 80.5 ± 8.3 | 70.5 ± 6.9 | 77.8 ± 6.0 |
Baseline values of ICI and MVP were averaged ICI and MVP measured for 10 minutes just before the initial BB injection (0.1 nmol/animal, i.c.v.). Baseline values of plasma noradrenaline and adrenaline were measured just before the initial BB injection. Baseline values of systolic, mean, and diastolic blood pressure were measured for 10 minutes just before the initial BB injection. Vehicle indicates Wistar rats treated with vehicle. BB indicates Wistar rats treated with BB. ADX plus BB indicates adrenalectomized Wistar rats treated with BB. Non-ADX indicates Wistar rats without adrenalectomy (i.e., a group combining vehicle and BB rats).
↵* P < 0.05 (compared with the Bonferroni method to the BB group);
↵† P < 0.05 (compared with the t test to the ADX plus BB group).