TABLE 2 

Reported cytokine/chemokine levels in FMS

CytokinesAssaysNaResultsReferences
IL-6, TNF-α (Serum)ELISA54:21 (IL-6), 43:17 (TNF-α)IL-6, TNF-αPresent results
IL-4, IL-6, IL-8, TNF-α (Serum)Bio-Plex cytokine assay20:80IL-8, TNF-α ↑ IL-6 ↓ IL-4, IL-10 →Wang et al. (2008)
IL-6, IL-8, TNF-α (Serum)Luminex56:32IL-8 ↓ IL-6, TNF-α → IL-6, IL-8, TNF-α ↓ in older FM patientsGarcia-Lozano et al. (2008)
IL-1, IL-6, IL-8 (Serum)ELISA81:32IL-8 ↑ IL-1, IL-6 →Gur et al. (2002)
IL-8 (Serum)ELISA20:20IL-8 ↑Bote et al. (2012)
IL-1α, IL-1β, IL-6, IL-8, TNF-α (Serum)Luminex7:12 
(Nonrespondersb)IL-6, IL-8↑Ross et al. (2010)
IL-1β, IL-6, IL-8 (Serum)ELISA27:29IL-8 ↑ IL-1β, IL-6 →Kim et al. (2010)
IL-1β, IL-6, TNF-α (Serum)ELISA64:25IL-6 ↑ IL-1β, TNF-αHernandez et al. (2010)
IL-6, IL-8 (Serum)ELISA105:61IL-8, IL-6 →Xiao et al. (2013)
IL-1β IL-6, IL-8, TNF-α (Serum)ELISA56:36IL-8 ↑ IL-1β, IL-6, TNF-αWallace et al. (2001)
IL-1β, IL-5, IL-6, IL-8, TNF-α (Serum)ELISA15:15IL-8 ↑ IL-1βKadetoff et al. (2012)
IL-1, IL-6, IL-8, TNF-α (Plasma)ELISA80:45IL-8, TNF-αBazzichi et al. (2007b)
IL-6, IL-8 (Plasma)Luminex39:47 (IL-6), 
62:43 (IL-8)IL-6, IL-8 ↓Behm et al. (2012)
  • a Number of FMS patients/number of healthy controls.

  • b Nonresponders did not increase growth hormone levels after exercise.