Effect of mDTA-1, muDX400, or combination pretreatments in the PK of DyLight 650–labeled muDX400 and mDTA-1
| Pretreatment Regimen | DyLight 650 Antibody | Dose | t1/2 | Cmax | AUClast | CL | Vss |
|---|---|---|---|---|---|---|---|
| mpk | day | μg/ml | hr·μg/ml | ml/day/kg | ml/kg | ||
| mDTA-1 + muDX400 3mg/kg Q7D × 2 | mDTA-1 | 30 | 0.5 | 81.4 | 3020.6 | 235.2 | 178.1 |
| Naive | muDX400 | 30 | 7.3 | 267.2 | 20717.6 | 10.1 | 106.4 |
| muDX400 3mg/kg Q7D × 2 | muDX400 | 30 | 7.4 | 290.5 | 22735.5 | 9.1 | 97.8 |
| mDTA-1 + muDX400 3mg/kg Q7D × 2 | muDX400 | 30 | 8.4 | 281.6 | 23259.4 | 8.2 | 99.3 |
AUClast, last area under the curve; CL, clearance.