The effects of ASB14780 and HFCD on the tissue weights, serum biomarker levels, and food intake of control and treated animals
The data are presented as the means ± S.E. for four to seven individuals (Tukey-Kramer post-hoc analysis).
| ASB(0)/ND (Group 1) | ASB(0.3)/ND (Group 2) | ASB(0)/HFCD (Group 3) | ASB(0.3)/HFCD (Group 4) | ASB(0→0.3)/HFCD (Group 5) | |
|---|---|---|---|---|---|
| Body weight (g)a | 27.5 ± 1.1 | 28.6 ± 1.3 | 37.3 ± 0.8** | 29.9 ± 1.1## | 30.8 ± 1.0## |
| Liver weight (g) | 1.12 ± 0.06 | 1.28 ± 0.10 | 1.44 ± 0.06* | 1.27 ± 0.04 | 1.35 ± 0.06 |
| Fat pad weight (g) | 0.72 ± 0.11 | 0.80 ± 0.10 | 2.25 ± 0.15** | 1.07 ± 0.06## | 1.31 ± 0.15## |
| Serum AST (IU/l) | 21.54 ± 0.91 | 22.67 ± 0.91 | 30.42 ± 2.57 | 31.46 ± 2.09 | 26.71 ± 1.84 |
| Serum ALT (IU/l) | 6.29 ± 0.52 | 5.57 ± 0.15 | 9.23 ± 1.43 | 7.16 ± 0.78 | 8.21 ± 1.02 |
| Food intake (g) | 2.79 ± 0.07 | 3.17 ± 0.12* | 2.68 ± 0.08 | 2.5 ± 0.07 | 2.40 ± 0.06 |