Agonist (5-HT) | | | | | | |
Min (µA) | 0 (fixed) | — | — | — | — | |
Max (µA) | 4.94 ± 0.64 | × EXP(ɳ2) | 0.95 ± 0.10 | H0: ω2,2=0 | No resulta | Max varies between oocytes |
COV(ɳ1,ɳ2) | | | 0.87 ± 0.05 | H0: ω1,2=0 | 4 × 10−9 | Max and pEC50 correlate strongly |
pEC50 | 5.65 ± 0.03 | + ɳ1 | 0.18 ± 0.02 | H0: ω1,1=0 | 4 × 10−35 | pEC50 varies between oocytes |
nH | 2.94 ± 0.13 | | | H0: nH(A)=3 | 0.64 | Suggests three highly cooperative agonist binding sites |
nT | −0.13 ± 0.06 | + ɳ7 | 0.19 ± 0.06 | H0: nT=0 | 0.052 | Weak evidence for a change in response with time |
H0: ω7=0 | 0.004 | nT varies between oocytes |
Citral | | | | | | |
pIC50 | 3.92 ± 0.05 | + ɳ5 | 0.16 ± 0.04 | H0: ω5=0 | 2 × 10−11 | pIC50 varies between oocytes |
nH | 1.34 ± 0.08 | | | H0: nH=1 | 5 × 10−6 | Indication of cooperative binding |
nG | 0 (fixed) | | | H1: {nG,pA2,nS}≠0 | 0.94 | No evidence that citral changes agonist pEC50 |
Eucalyptol | | | | | | |
pIC50 | 3.59 ± 0.11 | + ɳ4 | 0.32 ± 0.07 | H0: ω4=0 | 1 × 10−16 | pIC50 varies between oocytes |
nH | 1.04 ± 0.11 | | | H0: nH=1 | 0.76 | Suggests one inhibitor binding site |
nG | 1 (fixed) | | | H0: nG=0 | 4 × 10−15 | Strong evidence that eucalyptol changes agonist pEC50 |
pA2 | 3.09 ± 0.09 | + ɳ3 | 0.18 ± 0.06 | H0: ω3=0 | 0.006 | pA2 varies between oocytes |
nS | 1.70 ± 0.24 | | | H0: nS=1 | 0.001 | Schild slope greater than that for competitive antagonism |
Linalool | | | | | | |
pIC50 | 3.85 ± 0.02 | + ɳ6 | 0.05 ± 0.02 | H0: ω6=0 | 0.023 | pIC50 varies between oocytes |
nH | 2.19 ± 0.26 | | | H0: nH=2 | 0.46 | Suggests two highly cooperative inhibitor binding sites |
nG | 0 (fixed) | | | H1: {nG,pA2,nS}≠0 | 0.11 | No/weak evidence that linalool changes agonist pEC50 |
RUV model | | | | | | |
γ | 1.30 ± 0.07 | | | H0: γ=0 | 1 × 10−63 | Residual error variance increases with the current amplitude |
α | 0.30 ± 0.01 | | | | | |