TABLE 3

Effects of clorgyline, rasagiline, and selegiline on medium contents (fractions of control, means ± S.E.M.) of catechols after 180 minutes

Data shown only for three or more replicates. Numbers of replicates are in parentheses. To calculate variability for 0 concentration controls, the S.E.M.s and the mean values across the experiments were weighted, and then the sum of the weighted S.E.M.s was divided by the sum of the weighted means.

Drug	DOPAL	DOPAC	DOPET	DOPA	DA
No drug	1.00 ± 0.01 (23)	1.00 ± 0.03 (23)	1.00 ± 0.03 (23)	1.00 ± 0.03 (23)	1.00 ± 0.06 (23)
pmol/mL	188 ± 3	663 ± 23	491 ± 14	14.6 ± 0.4	146 ± 9
Clorgyline (nM)
1	0.20 ± 0.08 (8)^**	0.20 ± 0.05 (8)^**	0.29 ± 0.10 (8)^**	0.65 ± 0.02 (8)^**	2.28 ± 0.21 (8)^**
100	0.08 ± 0.02 (6)^**	0.11 ± 0.01 (6)^**	0.13 ± 0.00 (6)^**	0.74 ± 0.09 (6)^*	1.65 ± 0.32 (6)
1000	0.08 ± 0.01 (4)^**	0.13 ± 0.00 (4)^**	0.14 ± 0.00 (4)^**	0.85 ± 0.06 (4)	1.17 ± 0.03 (4)
10,000	0.15 ± 0.03 (8)^**	0.13 ± 0.02 (8)^**	0.17 ± 0.03 (8)^**	0.38 ± 0.06 (8)^**	1.96 ± 0.42 (8)^*
Rasagiline (nM)
1	1.05 ± 0.04 (3)	1.05 ± 0.07 (3)	1.1 2 ± 0.06 (3)	1.05 ± 0.03 (3)	1.13 ± 0.15 (3)
10	0.94 ± 0.07 (6)	0.88 ± 0.03 (6)^*	1.05 ± 0.08 (6)	0.94 ± 0.03 (6)	1.12 ± 0.07 (6)
100	0.49 ± 0.08 (10)^**	0.42 ± 0.06 (10)^**	0.64 ± 0.08 (10)^*	0.85 ± 0.04 (10)^*	1.24 ± 0.03 (10)
500	0.21 ± 0.00 (6)^**	0.27 ± 0.02 (6)^**	0.41 ± 0.02 (6)^**	0.59 ± 0.01 (6)^**	2.04 ± 0.04 (6)^**
1000	0.30 ± 0.02 (9)^**	0.28 ± 0.04 (9)^**	0.42 ± 0.03 (9)^**	0.74 ± 0.05 (9)^**	1.38 ± 0.02 (9)
10000	0.19 ± 0.02 (7)^**	0.16 ± 0.01 (7)^**	0.25 ± 0.01 (7)^**	0.67 ± 0.06 (7)^**	1.45 ± 0.27 (7)
Selegiline (nM)
500	0.26 ± 0.01 (6)^**	0.24 ± 0.02 (6)^**	0.42 ± 0.03 (6)^**	0.81 ± 0.16 (6)	1.90 ± 0.05 (6)^**
10,000	0.09 ± 0.00 (6)^**	0.14 ± 0.00 (6)^**	0.24 ± 0.03 (6)^**	0.59 ± 0.02 (6)^**	2.08 ± 0.17(6)^**

↵* Different from control by one-group t test, P < 0.05.
↵** P < 0.01.