TABLE 3 

Pressure-volume analysis of cardiac function at 4 weeks

All data are presented as mean ± S.E.M. Significance is presented as: *P < 0.05 versus CON.

CONTADiNOiNO-TAD
n =11n =13n =12n =13
HR (BPM)601 ± 12604 ± 14603 ± 15609 ± 13
LVESP (mmHg)78 ± 385 ± 489 ± 2*82 ± 3
LVEDP (mmHg)2.4 ± 0.62.1 ± 0.33.5 ± 0.72.3 ± 0.5
SV (μl)10.2 ± 0,911.0 ± 1.113.6 ± 1.114.9 ± 1.2*
CO (μl/min)6129 ± 5666637 ± 7138277 ± 7079156 ± 773*
EF (%)50.6 ± 454 ± 454 ± 459 ± 3
SW (mmHg x μl)771 ± 85932 ± 911205 ± 97*1134 ± 119
PRSW69 ± 871 ± 675 ± 1094 ± 8
Ea (mmHg/μl)7.8 ± 1.17.0 ± 0.56.3 ± 0.75.7 ± 0.3
Ees (mmHg/μl)10.1 ± 2.810.3 ± 1.56.7 ± 1.19.1 ± 2.2
Ea/Ees1.01 ± 0.160.79 ± 0.091.10 ± 0.140.83 ± 0.13
dP/dtmax (mmHg/s)8795 ± 9469956 ± 64611899 ± 87910617 ± 969
dP/dtmin (mmHg/s)−7498 ± 538−8248 ± 586−8930 ± 822−7837 ± 396
τ (ms)5.2 ± 0.25.2 ± 0.25.0 ± 0.35.1 ± 0.2
  • BPM, Beats per minute; CO, cardiac output; dP/dtmax and dP/dtmin, peak rate of systolic pressure rise and decline; Ea, arterial elastance; Ea/Ees ratio, ventricular-arterial coupling; Ees, left ventricular end-systolic elastance; EF, ejection fraction; HR, heart rate in; LVESP and LVEDP, left ventricular end systolic and end diastolic pressures; PRSW, preload-recruitable stroke work; SV, stroke volume; SW, stroke work; τ , tau time constant of isovolumic relaxation according to Weiss’ method.