PK Parameter | Population Estimate | Intersubject Variability |
---|---|---|
% rSE | % rSE | |
Ka (h−1) | 9.48 (9.35) | 29.5% (34.3) |
CL/F (liters/h) | 55.2 (12.9) | 46.4% (21.7) |
Vc/F (liters) | 561 (16.5) | 60.3% (33.9) |
Q/F (liters/h) | 59.3 (17.4) | 42.8% (40.0) |
Vp/F (liters) | 705 (27.4) | — |
Residual error | ||
Additive (ng/ml) | 0.09 (31.8) | |
Proportional | 12.8% (21.6) |
CL/F, apparent total body clearance of drug calculated after extravascular administration; Ka, transit absorption rate constant; Q/F, apparent intercompartmental clearance; rSE, relative standard error; Vc/F, apparent volume of distribution of the central component; Vp/F, apparent volume of distribution of the peripheral compartment.