TABLE 1

Pharmacokinetic and pharmacodynamic parameters of anti-mCD28 dAb-001 in mice or anti-hCD28 dAb-001 in monkeys

Parameter	Value Estimated (Mean ± S.D.)
	Mouse	Monkey
PK
k_a (hour⁻¹)	0.28 ± 0.045	0.029 ± 0.0023
k_el (hour⁻¹)	0.036 ± 0.0036	0.026 ± 0.0017
k_pt (hour⁻¹)	0.0065 ± 0.0044	0.016 ± 0.0028
k_tp (hour⁻¹)	0.040 ± 0.0075	0.022 ± 0.0026
V_c (l/kg)	0.077 ± 0.0088^a	0.033 ± 0.0011
F (%)	−	100 ± 6.1 (SC)
RO
E_max (%)	100 (fixed)	100 (fixed)
EC₅₀ (nM)	1.4 ± 0.088	7.6 ± 0.60
PD (KLH-induced IgG)
k_KLH (hour⁻¹)	−	0.0033 ± 0.00033
k_effect (hour⁻¹)	−	2.9 ± 0.39
τ (hour)	−	73 ± 3.7
Baseline IgG response	−	fixed at each dose level^b

↵^a V_c,apparent for the mouse data.
↵^b Based on the geometric mean of 4 animals at each dose group, the baseline IgG response was fixed at 42, 29, 33, and 121 for the vehicle group, 0.05, 0.5, and 5 mg/kg, respectively.