Pharmacokinetic and oral bioavailability data for MLi-2 in micea
| Parameter | 2 mg/kg IV | 10 mg/kg PO |
|---|---|---|
| AUC (μM⋅h) | 0.664 (7%) | 1.50 (52%) |
| Cmax (μM) | 0.716 (11%) | 0.298 (72%) |
| Tmax (h) | 0.75 (58%) | |
| MRT (h) | 2.7 (17%) | 11 (63%) |
| %F | 45 (52%) |
AUC, area under the curve; Cmax, maximum observed drug concentration; Tmax, time to maximum observed drug concentration; MRT, mean residence time; %F, oral bioavailability.
↵a Values are presented as mean (CV%), N = 3.