TABLE 1B

Effects of ischemia/reperfusion on the extratubular compartment in the testes of WT and KO sham, TI/R and CL of WT plus vehicle, BAY 11-7082– and BBG-treated WT, and KO mice at 1 day after the surgical procedure

Values are expressed as the mean ± S.E. Histologic grading of the extratubular compartment changes was based on the following scale: 0, absent; 1, mild; 2, moderate; and 3, severe.

	Extratubular Compartment
	Edema	Hemorrhagic Extravasation	Vascular Dilation	Leydig Cell Changes
Sham WT	0	0	0	0
Sham KO	0	0	0	0
WT TI/R + vehicle 1 day	2.1 ± 0.64^{^a}	1.55 ± 0.6^{^a}	1.15 ± 0.55^{^a}	1.25 ± 0.68^{^a}
WT CL + vehicle 1 day	0.95 ± 0.51	1.44 ± 0.59	1.05 ± 0.36	0.8 ± 0.55
WT TI/R + BAY 11-7082  1 day	0.41 ± 0.34^{^a}^,^{^b}	0.41 ± 0.11^{^a}^,^{^b}	0.38 ± 0.19^{^a}^,^{^b}	0.19 ± 0.22^{^a}^,^{^b}
WT CL + BAY 11-7082  1 day	0.3 ± 0.13	0.2 ± 0.14	0.33 ± 0.21	0.22 ± 0.19
WT TI/R + BBG 1 day	0.48 ± 0.33^{^a}^,^{^b}	0.66 ± 0.37^{^a}^,^{^b}	0.55 ± 0.53^{^a}^,^{^b}	0.23 ± 0.22^{^a}^,^{^b}
WT CL + BBG 1 day	0.29 ± 0.11	0.31 ± 0.14	0.32 ± 0.16	0.14 ± 0.24
KO TI/R 1 day	0.45 ± 0.51^{^c}	0.55 ± 0.44^{^c}	0.4 ± 0.41^{^c}	0.25 ± 0.36
KO CL 1 day	0.34 ± 0.47	0.25 ± 0.48	0.31 ± 0.5	0.25 ± 0.51

↵^a P < 0.05 versus sham WT mice.
↵^b P < 0.05 versus WT TI/R + vehicle mice.
↵^c P < 0.05 versus sham KO mice.