TABLE 2B

Effects of ischemia/reperfusion on the extratubular compartment in the testes of WT and KO sham, TI/R and CL of WT plus vehicle, BAY 11-7082– and BBG-treated WT, and KO mice at 7 days after the surgical procedure

Values are expressed as the mean ± S.E. Histologic grading of the extratubular compartment changes was based on the following scale: 0, absent; 1, mild; 2, moderate; and 3, severe.

	Extratubular Compartment
	Edema	Hemorrhagic Extravasation	Vascular Dilation	Leydig Cell Changes
Sham WT	0	0	0	0
Sham KO	0	0	0	0
WT TI/R + vehicle 7 days	2.25 ± 0.44^{^a}	0.92 ± 0.61^{^a}	1.07 ± 0.59^{^a}	0.55 ± 0.51^{^a}
WT CL + vehicle 7 days	1.85 ± 0.71	0.72 ± 0.3	0.65 ± 0.49	0.7 ± 0.65
WT TI/R + BAY 11-7082  7 days	0.66 ± 0.25^{^a}^,^{^b}	0.62 ± 0.27^{^a}	0.53 ± 0.14^{^a}	0.53 ± 0.4^{^a}
WT CL + BAY 11-7082  7 days	0.33 ± 0.19	0.49 ± 0.18	0.39 ± 0.22	0.41 ± 0.27
WT TI/R + BBG 7 days	0.55 ± 0.49^{^a}^,^{^b}	0.71 ± 0.35^{^a}	0.54 ± 0.44^{^a}^,^{^b}	0.44 ± 0.41^{^a}
WT CL + BBG 7 days	0.46 ± 0.33	0.42 ± 0.26	0.33 ± 0.31	0.26 ± 0.5
KO TI/R 7 days	0.62 ± 0.51^{^c}	0.65 ± 0.6^{^c}	0.65 ± 0.51^{^c}	0.35 ± 0.6
KO CL 7 days	0.47 ± 0.5	0.4 ± 0.41	0.35 ± 0.48	0.4 ± 0.41

↵^a P < 0.05 versus sham WT mice.
↵^b P < 0.05 versus WT TI/R + vehicle mice.
↵^c P < 0.05 versus sham KO mice.