Blood chemistries and tissue weights in wild-type normal C57Bl/6 mice following ISIS 486178 administration
Four mice per group were treated with 12.5 or 25 mg/kg body weight twice a week for 6 weeks. Values are expressed as means ± standard errors of means. There was no significant difference between PBS and ASO treatments on the blood chemistries and tissues weights using one-way analysis of variance, followed by Dunnett’s multiple comparison tests.
| Endpoint | Treatment Groups | ||
|---|---|---|---|
| PBS | 12.5 mg/kg ISIS 486178 | 25 mg/kg ISIS 486178 | |
| ALT (IU/l) | 33.25 ± 3.68 | 28.5 ± 0.29 | 32.5 ± 1.55 |
| AST (IU/l) | 60.75 ± 5.41 | 53.25 ± 8.29 | 46 ± 2.04 |
| BUN (IU/l) | 33.15 ± 3.53 | 25.925 ± 1.78 | 28.225 ± 1.52 |
| CK (U/l) | 134.5 ± 34.25 | 130.25 ± 41 | 89.25 ± 19.53 |
| Creatinine (mg/dl) | 0.1775 ± 0.02 | 0.1375 ± 0.01 | 0.145 ± 0.01 |
| Hematocrit (HCT) (%) | 49.25 ± 0.85 | 46.75 ± 1.11 | 46.25 ± 1.60 |
| Neutrophil (× 103) | 2956.25 ± 972.86 | 2063.75 ± 1000.82 | 2068 ± 1030.04 |
| Lymphocyte (× 103) | 6687.75 ± 377.86 | 7690.5 ± 424.42 | 5514 ± 711.37 |
| Platelet (× 103) | 1078.75 ± 171.71 | 1335.75 ± 135.45 | 1490.75 ± 51.71 |
| Tissue weights | |||
| Liver (g) | 1.36 ± 0.025 | 1.16 ± 0.178 | 1.64 ± 0.079 |
| Spleen (g) | 0.09 ± 0.007 | 0.11 ± 0.01 | 0.10 ± 0.004 |
| Kidney (g) | 0.33 ± 0.012 | 0.35 ± 0.017 | 0.34 ± 0.004 |
ALT, alanine transaminase; AST, aspartate transaminase; BUN, blood urea nitrogen; CK, creatine kinase.