TABLE 1

ED50 values in milligram per kilogram (95% confidence limits) for nicotinic drugs to produce antinociception in the assays of acid-stimulated stretching or acid-induced depression of ICSS

Acid-Stimulated StretchingAcid-Depressed ICSS
Nicotine0.14 (0.09–0.20)0.011 (0.006–0.023)†
5-I-A-853801.19 (0.48–2.97)*0.012 (0.006–0.021)†
PNU 282987InactiveInactive

  • ↵* Significantly different from nicotine ED50 within a given assay.

  • ↵† Significantly different from the ED50 for that drug in the assay of acid-stimulated stretching.