TABLE 3

Combretastatins induce mitotic catastrophe and cell death in endothelial and cancer-derived cells

CompoundCell TypeType of Cell DeathReference
CA-4EndothelialApoptosisIyer et al., 1998
CA-4NSCLCMitotic catastrophe and apoptosisVitale et al., 2007; Cenciarelli et al., 2008
CA-4Bladder cancerApoptosis, caspase-dependent and -independent cell deathShen et al., 2010
CA-4NSCLCCaspase-dependent mitotic catastrophe, apoptosis, intrinsicMendez et al., 2011; Méndez-Callejas et al., 2014
CA-4LeukemiaApoptosisGreene et al., 2010
CA-4Colon cancerCaspase-dependent apoptosisZhang et al., 2011
CA-4PEndothelialApoptosisAhmed et al., 2003
CA-4PEndothelialCaspase-independent, some hallmarks of apoptosisKanthou et al., 2004
CA-4PLeukemiaMitototic catastrophe and apoptosisNabha et al., 2002
CA-4PLeukemiaApoptosis, intrinsic, caspase-dependent and -independent cell deathPetit et al., 2008
4-Arylcoumarin CA-4 analogsLeukemiaApoptotic and nonapoptoticBailly et al., 2003
CA-4 Benso[b]thiophene and benzofuran analogsLung cancerApoptosisSimoni et al., 2006
4-Arylcoumarin CA-4 analogsHuman breastApoptosisRappl et al., 2006
MZ3 CA-4 analogLeukemiaApoptosis, intrinsicFang et al., 2007, 2008; Xu et al., 2008
Boronic acid analog CA-4LeukemiaApoptosisNakamura et al., 2006
Carbazole sulfonamide CA-4 analogBreast cancerApoptosisHu et al., 2006
ST2151 synthetic stilbenoid CA-4 analogsNSCLCMitotic catastrophe and apoptosis, intrinsicVitale et al., 2007
2,3-Diaryl-4/5-hydroxy-cycopent-2-en-1-one CA-4 analogsEndothelialApoptosisGurjar et al., 2007
Arylcoumarin combretastatin analogsLeukemiaApoptosis, intrinsic caspase-dependentBillard et al., 2008
XN0502 CA-4 analogNSCLCApoptosis, caspase-dependentZhu et al., 2010
1,5-Disubstituted 1,2,4-triazoles CA-4 analogsLeukemiaApoptosis, intrinsicRomagnoli et al., 2010
β -Lactam CA-4 analogsEndothelial, leukemia, ex vivo CML cells, cervical carcinoma, and breast cancerApoptosis, caspase-dependent Apoptosis, mitotic catastropheGreene et al., 2010, 2011; O'Boyle et al., 2011, 2013; Nathwani et al., 2013
Imidazole CA-4 analogsLeukemiaApoptosisSchobert et al., 2010
FPTB CA-4 analogChondrosarcomaApoptosis, intrinsicLiu et al., 2011
Thiazole CA-4 analogsCervical cancerMitotic catastrophe, apoptosis caspase-dependent and- independentRomagnoli et al., 2011
1,5-Disubstituted tetrazoles CA-4 analogsCervical cancerApoptosis, intrinsicRomagnoli et al., 2012
DAT-230 CA-4 analogFibrosarcoma; gastric adenocarcinomaApoptosis, intrinsicQiao et al., 2012, 2013
Cyclopropylamide analog CA-4Lung cancerApoptosisChen et al., 2013
3-(Trimethoxyphenly)-2(3H)-2(3H)-thiazole thiones CA-4 analogsBreast cancerApoptosisBanimustafa et al., 2013
CA-4E containing 3′-O–substituted carbonic etherBreast cancerApoptosisMa et al., 2013
1,2,3-Triazole CA-4 analogLeukemiaApoptosis, mitotic catastropheDemchuk et al., 2014
1,2,3-Triazole–linked aminocombretastatin conjugatesLung cancerApoptosisKamal et al., 2014a
G-1103 CA-4 analogFibrosarcomaApoptosis, intrinsic and extrinsicZuo et al., 2015
Biaryl CA-4 analogsOsteosarcoma, leukemiaApoptosisMcNulty et al., 2015
  • CML, chronic myeloid leukemia; DAT-230, 2-methoxy-5-(2-(3,4,5-trimethoxyphenyl) thiophen-3-yl)aniline; FPTB, 2-(furanyl)-5-(pyrrolidinyl)-1-(3,4,5-trimethoxybenzyl) benzoimidazole; G-1103, 3-(3-hydroxy-4-methoxyphenyl)-4-(3,4,5-trimethoxyphenyl)-1,2,5-selenadiazole; MZ3, (4-(4-bromophenyl)-2,3-dihydro-N,3-bis(3,4,5-trimethoxyphenyl)-2-oxoidmi-dazole-1-carboxamide); XN0502, 4-(4-methoxphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-pyrazol-3-amine.