TABLE 2

Combretastatins induce G2/M cell cycle arrest in a broad spectrum of normal and carcinoma-derived cell lines

CompoundCell TypeReference
CA-4PEndothelialKanthou et al., 2004; Ding et al., 2011
CA-4Malignant human B-lymphoidNabha et al., 2001
CA-4PLeukemiaPetit et al., 2008
CA-4Hepatocellular carcinomaQuan et al., 2008
CA-4Nonsmall cell lung cancer (NSCLC)Cenciarelli et al., 2008
CA-4Bladder cancerShen et al., 2010
CA-4Leukemia, cervicalGreene et al., 2010, 2011
CA-4NSCLCMéndez-Callejas et al., 2014
CA-4–like ethersLeukemiaLawrence et al., 2001
Naphthalene CA-4 analogsCervical, colon, and lung carcinomaMaya et al., 2005
β-Lactam CA-4 analogsEndothelial, leukemia, cervical, breast, and colon carcinomaCarr et al., 2010; Greene et al., 2010, 2011, 2012; Nathwani et al., 2013; O'Boyle et al., 2011, 2013
Benzo[b]thiophene and benzofuran combretastatin analogsLung cancerSimoni et al., 2006;
Carbazole sulfonamide CA-4 analogBreast cancerHu et al., 2006
N-phenyl-N′-(choroethyl)urea derivativesMelanomaFortin et al., 2007
4/5-Hydroxy-2,3-diaryl(substituted)-cycopent-2-en-1-ones CA-4 analogsEndothelial cancerGurjar et al., 2007
MZ3 CA-4 analogLeukemiaFang et al., 2008
Benzil derivatives of CA-4Colon cancer and NSCLMousset et al., 2008
2,5-Diaryl-2,3-dihydro-1,3,4-oxadiazoline CA-4 analogCervicalLee et al., 2010
XN0502 CA-4 analogNSCLCZhu et al., 2010
DAT-230 CA-4 analogFibrosarcomaQiao et al., 2012, 2013
Combretastatin-amidobenzothiazole conjugateBreast carcinomaKamal et al., 2012
3,5-Dihalogenation A-ring tetrazolesOvarian carcinomaBeale et al., 2012
Cyclopropylamide CA-4 analogLung carcinomaChen et al., 2013
3,4-Diaryl squaric acid CA-4 analogBreast carcinomaLiu et al., 2013
2-Alkylthio-4-(2,3,4-trimethoxyphenyl)-5-aryl-thiazole CA-4 analogsMouse embryonic fibroblastSalehi et al., 2013
CA-4 derivatives containing a 3′-O-substituted carbonic ether moietyBreast cancerMa et al., 2013
TR-644 CA-4 analogEndothelialPorcù et al., 2013
1,2,3-Triazole CA-4 analogLeukemiaDemchuk et al., 2014
3,4-Diaryl-1,2,5-selenadiazol analogColon cancerGuan et al., 2014
Benzo[b]furan combretastatin analogLung cancerKamal et al., 2014b
1,2,3-Trizole–linked aminocombretastatin conjugatesLung cancerKamal et al., 2014a
COH-203 CA-4 analogLiver cancerQi et al., 2014
G-1103 CA-4 analogCervical and fibrosarcomaZuo et al., 2015
  • COH-203, 5-(3-hydroxy-4-methoxyphenyl)-4-(3,4,5-trimethoxyphenyl)-3H-1,2-dithiol-3-one; DAT-230, 2-methoxy-5-(2-(3,4,5-trimethoxyphenyl) thiophen-3-yl)aniline; G-1103, 3-(3-hydroxy-4-methoxyphenyl)-4-(3,4,5-trimethoxyphenyl)-1,2,5-selenadiazole; MZ3, (4-(4-bromophenyl)-2,3-dihydro-N,3-bis (3,4,5-trimethoxyphenyl)-2-oxoidmi-dazole-1-carboxamide); TR-644, 2-amino-4-(3′,4′,5′-trimethoxyphenyl)-5-aryl thiazole; XN0502, 4-(4-methoxphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-pyrazol-3-amine.