TABLE 4

Modulation of human and mouse NaCT by lithium

Data are expressed as means ± S.E. except for EC50/IC50 values, which are expressed as means (95% confidence intervals). In the fields in which no values are given (indicated by dashes) the effects of lithium were too small to fit a curve to the data.

[Citrate]EmaxEC50/IC50nHn
μM%mM
Human NaCT100536 ± 244.0 (2.9–5.6)1.08 ± 0.113
Human NaCT300287 ± 312.0 (0.6–6.7)0.86 ± 0.263
Human NaCT100052 ± 40.9 (0.4–1.6)1.34 ± 0.423
Human NaCT300033 ± 30.9 (0.7–1.1)1.49 ± 0.223
Mouse NaCT1292 ± 631.7 (0.3–11.7)0.95 ± 1.013
Mouse NaCT1004