TABLE 1

Statistical analyses

Factor EffectInteraction Effect
Overall effects for Fig. 2
Acute antidepressant effects Factor ‘treatment’Factor ‘pretreatment’Factor ‘pretreatment’ × ‘treatment’
Forced-swim testF[6,83] = 4.10P < 0.01
Glycine, forced-swim testF[1,53] = 7.57P < 0.001F[1,53,] = 7.50P < 0.001F[1,53] = 6.55P = 0.01
NBQX, forced-swim testF[2,65] = 4.51P < 0.05F[1,65] = 16.80P < 0.001F[2,65] = 6.16P < 0.01
Tail-suspension testF[4,74] = 3.57P < 0.05
NSF latency to feedF[2,27] = 10.51P < 0.001
Home-cage food consumptionF[2,27] = 0.53P = 0.60
Overall effects for Fig. 3
Sustained antidepressant effects, 24-hour FST Factor ‘treatment’
Immobility timeF[4,45] = 11.84P < 0.001
Sustained antidepressant effects, LH
Effects of 4-Cl-KYN (24 hours)F[2,28] = 71.68P < 0.001
Effects of 4-Cl-KYN (7 days)F[2,28] = 43.78P < 0.001
Effects of 7-Cl-KYN (24 hours)F[4,39] = 11.47P < 0.001
Effects of 7-Cl-KYN (7 days)F[4,39] = 4.23P < 0.01
Overall effects for Fig. 4Effects of 4-Cl-KYN in the open-field test Factor ‘treatment’Factor ‘time’Factor ‘treatment‘ × ‘time‘
Acute locomotor effectsF[3,28] = 0.35P = 0.79F[23,644] = 29.73P < 0.001F[69,644] = 6.72P < 0.001
Locomotor sensitizationF[3,28] = 16.08P < 0.001F[8,224] = 8.87P < 0.001F[24,168] = 11.34P < 0.001
Circling behaviorF[3,28] = 8.04P < 0.001
Rearing activityF[3,28] = 3.39P < 0.05F[8,224] = 7.86P < 0.001F[24,224] = 2.87P < 0.001
Overall effects for Fig. 5
4-Cl-KYN effects in CPP Factor ‘treatment’Factor ‘CPP phase’Factor ‘treatment’ × ‘CPP phase’
Time in drug-paired compartmentF[3,27] = 1.71P = 0.19F[1,27] = 11.71P < 0.01F[3,27] = 4.34P < 0.05
ratio (Post-Cond/Pre-Cond)F[3,27] = 4.40P < 0.05
PPI, Ketamine dose-responseFactor ‘treatment’Factor ‘intensity’Factor ‘treatment’ × ‘intensity’
% PPIF[4,148] = 15.83P < 0.001F[2,148] = 25.40P < 0.001F[8,148] = 0.33P = 0.95
Startle amplitudeF[4,51] = 0.51P = 0.73
PPI, Effects of 4-Cl-KYNFactor ‘treatment’Factor ‘intensity’Factor ‘treatment’ × ‘intensity’
% PPIF[4,153] = 23.33P < 0.001F[2,153] = 16.57P < 0.001F[8,153] = 0.74P = 0.66
Startle amplitudeF[4,54] = 0.99P = 0.42
Effects of 7-Cl-KYNA in the FST 
Antidepressant effects Factor ‘treatment’
Immobility timeF[3,27] = 4.121P < 0.05