TABLE 3

Pharmacokinetic parameters of five novel 2-AMTs

Compound	EC₅₀	Tissue	Oral Gavage, 10 mg/kg			3-Day Feeding
Compound	EC₅₀	Tissue	C_max	t_max	AUC_last	C_3day	Dose	Excipient
	µM		µM	hours	µM⋅h	µM
IND114338	0.068^{^a}	Brain	2.5^{^a}	2	10.9^{^a}	0.15	25	0.5% CMC
						2.9	210	0.5% CMC
						13.3	200	0.125% PEG400
		Plasma	4.1	2	15.6^{^a}	0.24	25	0.5% CMC
						3.1	210	0.5% CMC
						4.7	200	0.125% PEG400
IND124	0.124	Brain	2.8	0.25	3.8	0.005	200	0.125% PEG400
IND124	0.124	Plasma	1.2	0.25	1.4	0.003	200	0.125% PEG400
IND125	0.057	Brain	1.1	4.0	4.3	49	200	0.125% PEG400
IND125	0.057	Plasma	0.8	4.0	2.9	6.0	200	0.125% PEG400
IND126	0.228	Brain	3.6	4.0	4.3	0.04	200	0.125% PEG400
IND126	0.228	Plasma	0.3	4.0	0.5	0.02	200	0.125% PEG400
IND126461	0.070^{^a}	Brain	0.1^{^a}	0.5	0.2^{^a}	0.10	200	0.125% PEG400
IND126461	0.070^{^a}	Plasma	0.1	4	0.4^{^a}	0.20	200	0.125% PEG400