Dose | Cmax | Tmax | AUC0-t | AUC0-inf | DN_Cmax | DN_AUC0-inf | t1/2 |
---|---|---|---|---|---|---|---|
(mg/kg) | (ng/ml) | (h) | (h × ng/ml) | (ng/ml) | (h × ng/ml) | (h) | |
3 | 1199 | 0.7 | 5980 | 6543 | 399 | 2181 | 5.7 |
(n = 5)a | ± 173 | ± 0.15 | 823 | ± 1,010 | ± 59 | ± 337 | ± 0.91 |
9 | 3,120 | 0.6 | 19,465 | 22,050 | 347 | 2,450 | 5.9 |
(n = 6) | ± 289 | ± 0.08 | ± 2086 | ± 2848 | ± 32 | ± 316 | ± 0.47 |
AUC0–t, area under plasma drug concentration versus time curve from time of dose administration (time zero) to the last time point with measureable drug concentration; AUC0-inf, AUC from time of drug administration with extraphypolation to infinity; DN_Cmax, dose-normalized Cmax; DN_AUC0-inf, dose-normalized AUC0–inf.
↵a One animal with levels much lower than the other dogs and not detectable after 6 hours was excluded. At 9 mg/kg, the same dog had plasma levels that were similar to those of the other dogs at the 9 mg/kg dose.