TABLE 1

Inhibitory effects of SGLT inhibitors on SGLT1 and SGLT2

All values are expressed as the geometric mean of two to three experiments.

IC50
HumanRatMouse
SGLT1SGLT2SGLT1SGLT2SGLT1SGLT2
nmol/l
Phloridzin24123.860949.176065.6
CGMI22.11.3939.42.7341.56.31
Canagliflozina6634.25553.76135.6
• a Data from Kuriyama et al. (2014).