TABLE 1

Lipid analysis in plasma by mass spectrometry

P values were calculated using Student’s unpaired two-tailed t test. Control group consists of mock-treated uninfected animals; HIV group, HIV-infected mock-treated animals; preTO + HIV group, animals pretreated with T0901317 and then infected with HIV (results for nonrespondent mouse, which was infected and maintained virus load on weeks 6 and 8, is shown in a separate column).

	Mean ± S.E.M. (nmol/mg Total Lipid)				P Values
Lipid Class	Control	HIV	preTO + HIV		Control versus HIV	Control versus preTO + HIV	HIV versus preTO + HIV
Lipid Class	Control	HIV	All	Nonrespondent	Control versus HIV	Control versus preTO + HIV	HIV versus preTO + HIV
LysoPC	10 ± 7.7	49 ± 8.1	20 ± 3.8	33.9	0.03^{^a}	0.22	0.006^{^a}
PC	61 ± 51	193 ± 24	115 ± 18	186	0.04^{^a}	0.21	0.031^{^a}
EtherPC	10 ± 8.2	10 ± 1.2	8 ± 1.1	11.2	0.97	0.54	0.283
LysoPE	0.02 ± 0.01	0.09 ± 0.03	0.05 ± 0.01	0.11	0.23	0.26	0.229
SM, DSM	7 ± 5.6	19 ± 2.7	11 ± 2.4	19	0.051	0.44	0.080
PE	0.02 ± 0.02	0.02 ± 0.003	0.03 ± 0.01	0.05	0.76	0.48	0.159
PI	0.42 ± 0.4	8.42 ± 1.9	2.90 ± 0.6	5.56	0.01^{^a}	0.01^{^a}	0.015^{^a}
PS	0.04 ± 0.04	0.06 ± 0.01	0.09 ± 0.01	0.09	0.54	0.14	0.102
PA	0.14 ± 0.13	0.08 ± 0.02	0.06 ± 0.01	0.03	0.35	0.12	0.452
Chol Ester	645 ± 485	1579 ± 435	649 ± 97	886	0.22	0.99	0.056

Chol Ester, cholesterol ester; DSM, dihydrosphingomyelin; EtherPC, ether-linked phosphatidylcholine; LysoPE, lysophosphatidylethanolamine; PA, phosphatidic acid; PE, phosphatidylethanolamine; PS, phosphatidylserine; SM, sphingomyelin.
↵^a Significant difference.