Comparison between LY2951742 and placebo in the percentage change from baseline in DBF, with correction for baseline by time and dose group
Values presented are percentages. Mixed model repeated measures for change from predose in percentage change DBF induced by capsaicin, with time, dose group, and time*dose group as the fixed effects, percentage change DBF at predose as the covariate, and subject within time as the random effect.
| Time Point | Placebo | LY2951742 | |||||
|---|---|---|---|---|---|---|---|
| n = 12 | 1 mg (n = 7) | 5 mg (n = 7) | 25 mg (n = 7) | 75 mg (n = 7) | 200 mg (n = 7) | 600 mg (n = 7) | |
| Screening | |||||||
| Mean (S.D.) | 352.638 (94.100) | 402.437 (57.995) | 357.236 (103.165) | 341.696 (106.793) | 243.887 (128.108) | 323.615 (127.695) | 313.507 (114.920) |
| Day 3 | |||||||
| Mean (S.D.) | 339.298 (118.864) | 345.932 (102.355) | 294.313 (173.142) | 247.678 (124.550) | 144.182 (174.123) | 181.639 (135.991) | 107.649 (71.093) |
| P value | 0.701 | 0.3797 | 0.1169 | 0.0167 | 0.0112 | 0.0003 | |
| Day 14 | |||||||
| Mean | 319.094 (119.201) | 359.752 (112.561) | 239.643 (147.769) | 192.185 (88.115) | 150.997 (133.821) | 94.965 (104.620) | 109.630 (44.202) |
| P value | 0.7879 | 0.0994 | 0.0169 | 0.0347 | 0.0001 | 0.0004 | |
| Day 28 | |||||||
| Mean | 359.224 (102.101) | 336.811 (133.196) | 229.995 (167.174) | 166.956 (98.012) | 112.730 (118.482) | 120.528 (106.202) | 81.838 (42.581) |
| P value | 0.2871 | 0.0063 | 0.0002 | 0.0002 | <0.0001 | <0.0001 | |
| Day 42 | |||||||
| Mean | 350.035 (107.829) | 344.652 (108.296 | 182.433 (84.312) | 211.923 (94.621) | 95.413 (70.599) | 161.518 (108.563) | 91.788 (35.087) |
| P value | 0.36 | <0.0001 | 0.0005 | <0.0001 | <0.0001 | <0.0001 | |