TABLE 1

HTO and triolein decrease the phase transition temperature of the membrane lamellar-to-hexagonal phase (HII)

Differential scanning microcalorimetry was performed on POPE membranes in the presence or absence of 1% of HTO or triolein.

Model MembraneTm∆HTH∆H
°Ckcal/mol°Ckcal/mol
POPE23.6 ± 0.24.42 ± 0.0369.1 ± 0.50.42 ± 0.03
+ Triolein23.3±0.24.55 ± 0.09a60.8 ± 3.3b0.24 ± 0.11b
+ HTO23.8 ± 0.35.78 ± 0.08b66.0 ± 0.9a0.55 ± 0.06b

  • ΔH, transition enthalpy; TH, lamellar-to-hexagonal (HII) phase-transition temperature; Tm, gel-to-liquid crystalline (lamellar) phase-transition temperature.

  • ↵a POPE versus triolein or HTO, P < 0.01.

  • ↵b POPE versus triolein or HTO, P < 0.001.