TABLE 4

Urinary DM/DX ratios for CTP-347 on days 1 and 14

	Urinary DM/DX
	Baseline	Day 14
CTP-347 10 mg daily
Patient no.
49	0.0110	0.0260
52	0.9720^{^a}	1.4050^{^a}
54	0.0150	0.0720
55	0.0001	0.0050
56	0.0020	0.0070
57	0.0020	0.0050
58	0.0040	0.0090
59	0.0010	0.0040
60	0.0180	0.1050
Mean	0.1139	0.1820
S.D.	0.3219	0.4600
Median	0.0040	0.0090
CTP-347 10 mg twice daily
Patient no.
85	0.0140	0.1640
86	0.0010	0.0020
88	0.0002	0.0010
89	0.0010	0.0050
90	0.0160	0.3530 ^a
91	0.0020	0.0330
92	0.0010	ND
Mean	0.0050	0.0930
S.D.	0.0069	0.1419
Median	0.0020	0.0985
CTP-347 20 mg daily
Patient no.
61	0.0030	0.0270
62	0.0050	0.2580
63	0.1020	0.2530
64	0.0020	0.0220
66	0.0040	0.0430
67	0.0380	0.1230
69	0.0090	0.4820^{^a}
71	0.0070	0.3120^{^a}
72	0.0060	0.0500
Mean	0.0196	0.1744
S.D.	0.0328	0.1609
Median	0.0060	0.1230
CTP-347 40 mg daily
Patient no.
74	0.0040	0.1670
75	0.0030	0.0730
77	0.0010	0.1800
78	0.0380	0.8500^{^a}
79	0.0010	0.1370
81	0.0020	0.7230^{^a}
82	0.0010	0.1200
83	0.0010	0.4960^{^a}
84	0.0110	0.3880^{^a}
Mean	0.0069	0.3482
S.D.	0.0121	0.2849
Median	0.0020	0.1800

ND, not determined.
↵^a Poor metabolizer.