Effect of chronic treatment with RAN on systemic blood pressure and heart rate in animals with MCT-induced PAH
Measurements were performed at 28 days after injection of MCT (60 mg/kg body weight). One week after MCT injection, two groups of rats were switched to a diet containing either 0.25 or 0.5% RAN by weight.
| Sham | PAH | PAH Plus 0.25% RAN | PAH Plus 0.5% RAN | |
|---|---|---|---|---|
| Mean arterial pressure (mm Hg) | 95 ± 6.9 | 89 ± 7.6* | 100 ± 5.2 | 99 ± 1.7 |
| Heart rate (beats/min) | 291 ± 17 | 292 ± 12 | 313 ± 13 | 300 ± 21 |
↵* P < 0.05 versus sham.