TABLE 2

Effect of oral GSK2041706 and metformin singly or in combination on serum chemistries in fed DIO mice

Data are mean ± S.E.M. Blood samples were collected on day 14, 1 hour post–9:00 AM dosing. n = 8 mice/group.

Treatment	GLU	CHOL	HDL-C	TRIG	NEFA	GLYC	β-HBA
	mg/dl				mEq/l	mg/dl
Vehicle	227 ± 11.6	261.9 ± 10.4	106.9 ± 2.2	58.5 ± 3.3	0.35 ± 0.01	16.8 ± 0.9	1.3 ± 0.1
GSK2041706 (30 mg/kg)	243.6 ± 9.9	211.4 ± 13.1^*	96.8 ± 2.1^*	51.8 ± 3.4	0.37 ± 0.02	15.5 ± 0.7	2.1 ± 0.1^*
Metformin (30 mg/kg)	220.8 ± 10.1	257.3 ± 6.8	109.1 ± 2.6	58.9 ± 2.9	0.4 ± 0.01^*	13.8 ± 1.4^*	1.4 ± 0.3
Metformin (100 mg/kg)	189.3 ± 3.2^*	240.3 ± 7.9	102.3 ± 1.6	54.4 ± 0.8	0.42 ± 0.01^*	13.3 ± 1^*	2.1 ± 0.1^*
GSK2041706 + metformin  (30 mg/kg)	206.8 ± 4.7	221.6 ± 5.8^*	98.8 ± 2.1^*	45.1 ± 1.3^*	0.4 ± 0.01^*	12.1 ± 0.7^*	2.2 ± 0.2^*
GSK2041706 + metformin  (100 mg/kg)	206.3 ± 5.8	181.1 ± 8.2^*	89 ± 3^*	33 ± 2.7^*	0.33 ± 0.01	10.9 ± 0.7^*	3.3 ± 0.4^*

CHOL, cholesterol; GLU, glucose; GLYC, glycerol; β-HBA, β-hydroxybutyric acid; HDL-C, high-density lipoprotein cholesterol; NEFA, nonesterified fatty acids; TRIG, triglycerides.
↵* P < 0.05 versus vehicle.