Summary of pulmonary hemodynamics, RV hypertrophy, and heart rate data from animals subjected to ISO challenge
All rats with PAH had a similar PAH phenotype before the administration of ISO (0.1 mg/kg i.v.). Of note, ISO induced similar increases in heart rate across groups.
| Sham | PAH | |
|---|---|---|
| Baseline systolic pulmonary pressure (mm Hg) | 25 ± 4 | 41 ± 9* |
| RV hypertrophy (mg/mm) | 6.7 ± 0.7 | 10.5 ± 2* |
| Baseline heart rate (beats/min) | 315 ± 55 | 280 ± 30* |
| Increase in heart rate after ISO challenge (beats/min) | 108 ± 28 | 96 ± 30 |
↵* P < 0.05 versus sham.