TABLE 1

The effect of AZD5069 on mean blood neutrophil numbers 4 hours after LPS challenge

Group No.	Treatment/Challenge	Blood Neutrophils (Mean ± S.E.M.)^{^a}
1	Vehicle p.o./saline challenge	1.62 ± 0.16
2	Vehicle p.o./LPS challenge	3.16 ± 0.17
3	AZD5069 (0.3 μmol/kg)/LPS challenge	2.78 ± 0.09
4	AZD5069 (1 μmol/kg)/LPS challenge	2.44 ± 0.20^*
5	AZD5069 (3 μmol/kg)/LPS challenge	1.81 ± 0.17**
6	AZD5069 (10 μmol/kg)/LPS challenge	1.37 ± 0.25**
7	Dexamethasone (5.8 μmol/kg)/LPS challenge	1.96 ± 0.10**
8	AZ10397767 (120 μmol/kg)/LPS challenge	2.04 ± 0.20**

↵^a Data are given as number of cells per ml × 10⁶.
* P < 0.05, **P < 0.001 when compared with the vehicle treated control group (group 2) using analysis of variance followed by Bonferroni multiple comparisons test.