Sensitivity of different human cell lines to selected compounds
Data are presented as IC50 values (concentration of an inhibitor that is needed for 50% inhibition of cell proliferation at 72 hours), with means ± S.E.M. of at least two independent experiments each performed in triplicate.
| Compound | Cell Line | |||
|---|---|---|---|---|
| HT-29 | SW-620 | SW-620-5FuR | CCD18Co | |
| μM | ||||
| 5-FU | — | 7.1 ± 1.3 | >5000.0 | <3.0 |
| EA | 95.0 ± 10.4 | 79.0 ± 4.0 | 45.0 ± 5.0 | 37.5 ± 2.5 |
| 3,3′-DiOMEA | 106.0 ± 3.3 | 72.5 ± 2.5 | 145.0 ± 5.0 | 47.5 ± 2.5 |
| 4,4′-DiOMEA | 7.6 ± 1.5 | 5.8 ± 1.6 | 28.8 ± 3.2 | 59.5 ± 4.55 |
| Uro-A | 38.5 ± 3.5 | 26.0 ± 1.0 | — | — |
| Uro-B | ns | ns | — | — |
| Resveratrol | 90.0 ± 10.0 | 35.0 ± 1.1 | — | — |
| Homovanillic acid | ns | — | — | — |
| Gallic acid | ns | — | — | — |
| Dihydrocaffeic acid | ns | — | — | — |
| 4-O-Methylgallic acid | ns | — | — | — |
| 3-O-Methylgallic acid | ns | — | — | — |
—, not determined; ns, no significant activity found at assayed concentrations.