TABLE 1

G protein localization in the kidney

Summary of the vascular and nephron segments that have been identified for Gα subunits in the kidney. Techniques used to determine the presence of the Gα subunits are indicated with lettered footnotes.

Gα SubunitGlomerulusProximal Convoluted TubuleThick Ascending LimbCollecting DuctPreglomerular Blood Vessels
Gs+a,b+a,c+c,d+c,d+b
Gi1+bcd, +cd+b,d
Gi2+b,cc+d, −c+c,d+b
Gi3+b,c+cd, +cd +b
Go+bN/Ddd N/D
Gq+b− (+ through its interaction with GPCR)d d +b
G11+bN/Dd +d+b
G14N/DN/Dd +dN/D
G15/16N/DN/DN/DN/DN/D
G12+c+c+c+c+c
G13c+cc+c+c
  • +, positive; −, negative; N/D, not determined.

  • a In situ hybridization.

  • b Western blot analysis of isolated segments.

  • c Immunohistochemistry.

  • d Microdissection of renal tubular segments followed by RT-PCR.